BMS-665053

• Target:

  Others|||CRFR

• Related Pathways:

  Others|||GPCR/G Protein

• Bioactivity:

  BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM) that inhibits CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM) . It is also efficacious in the Defensive Withdrawal model of anxiety in rats and has low in vivo clearance [Cl = 17 mL/min/kg, t½ = 7.8 h].

• Smiles:

  [C@@H](C)(N1C(=O)C(NC2=C(Cl)C=C(OC(F)F)C=C2Cl)=NC(Cl)=C1)C3CC3

• Molecular Formula:

  C16H14Cl3F2N3O2

• Molecular Weight:

  424.66

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1173435-64-7