BMS 182874

• Target :

  Endothelin Receptor

• Related Pathways :

  GPCR/G Protein

• Purity :

  0.9973

• Bioactivity :

  BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 ?M for ETA and a Ki value of 0.055 ?M for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease.

• Smiles :

  S(NC1=C(C)C(C)=NO1)(=O)(=O)C=2C3=C(C(N(C)C)=CC=C3)C=CC2

• Molecular Formula :

  C17H19N3O3S

• Molecular Weight :

  345.42

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  153042-42-3