BMS 182874

• Target:

  Endothelin Receptor

• Related Pathways:

  GPCR/G Protein

• Purity:

  0.9973

• Bioactivity:

  BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 ?M for ETA and a Ki value of 0.055 ?M for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease.

• Smiles:

  S(NC1=C(C)C(C)=NO1)(=O)(=O)C=2C3=C(C(N(C)C)=CC=C3)C=CC2

• Molecular Formula:

  C17H19N3O3S

• Molecular Weight:

  345.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  153042-42-3