(R)-(-)-Gossypol

(R)-(-)-Gossypol

• CAS Number: 90141-22-3
• UNSPSC Description: (R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
• Target Antigen: Autophagy; Bcl-2 Family
• Type: Natural Products
• Related Pathways: Apoptosis;Autophagy
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/AT-101.html
• Solubility: DMSO : ≥ 200 mg/mL
• Smiles: OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O
• Molecular Weight: 518.55
• References & Citations: [1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.|[2]Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.Cancer Lett. 2019 Oct 1;461:31-43. |Clin Transl Med. 2021 Jun;11(6):e467.|Patent. US20220162561A1.|Microb Pathog. 2024 Sep 21:106960.|Transbound Emerg Dis. 2023 Nov 11.|Nat Commun. 2023 Jun 10;14(1):3445.|Patent. US20220162561A1.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 3