Gossypol

• Description:

  Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

• Product Name Alternative:

  BL 193

• UNSPSC:

  12352005

• Hazard Statement:

  H360

• Target:

  Bcl-2 Family

• Type:

  Natural Products

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Gossypol.html

• Purity:

  99.67

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles:

  O=CC1=C(O)C(O)=C(C(C)C)C2=CC(C)=C(C3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O)C(O)=C12

• Molecular Formula:

  C30H30O8

• Molecular Weight:

  518.55

• Precautions:

  H360

• References & Citations:

  [1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-) -Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10 (22) :7757-63.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Bcl-2; Bcl-xL

• Citation 01:

  Microb Pathog. 2024 Sep 21:106960.|Toxics. 2025 Sep 9;13 (9) :763.|Transbound Emerg Dis. 2023 Nov 11:2023:9073566.|Cell Rep. 2025 Apr 16;44 (5) :115572.|Clin Transl Med. 2021 Jun;11 (6) :e467.|Patent. US20220162561A1.|Toxicol Sci. 2025 Oct 24:kfaf149.|Nat Commun. 2023 Jun 10;14 (1) :3445.|Patent. US20220162561A1.

• CAS Number:

  [303-45-7]