Gossypol

• UNSPSC Description:

  Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

• Target Antigen:

  Bcl-2 Family

• Type:

  Natural Products

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Gossypol.html

• Smiles:

  O=CC1=C(O)C(O)=C(C(C)C)C2=CC(C)=C(C3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O)C(O)=C12

• Molecular Weight:

  518.55

• References & Citations:

  [1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.Microb Pathog. 2024 Sep 21:106960.|Transbound Emerg Dis. 2023 Nov 11.|Cancer Lett. 2019 Oct 1;461:31-43. |Clin Transl Med. 2021 Jun;11(6):e467.|Patent. US20220162561A1.|Nat Commun. 2023 Jun 10;14(1):3445.|Patent. US20220162561A1.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  303-45-7