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Lansoprazole

CAT: 0804-HY-13662-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13662-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) [1][2].
CAS Number
103577-45-3
Product Name Alternative
AG-1749
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Phospholipase; Proton Pump
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/lansoprazole.html
Purity
99.92
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : 10 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=S(C1=NC2=CC=CC=C2N1)CC3=NC=CC(OCC(F)(F)F)=C3C
Molecular Formula
C16H14F3N3O2S
Molecular Weight
369.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Kokufu, T., et al., Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. Eur J Clin Pharmacol, 1995. 48 (5) : p. 391-5.|[2]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.|[3]Rupinder K Sodhi, et al. Defensive effect of lansoprazole in dementia of AD type in mice exposed to streptozotocin and cholesterol enriched diet. PLoS One. 2013 Jul 31;8 (7) :e70487.|[4]Jun Matsukawa, et al. A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands. Biochem Pharmacol. 2011 May 1;81 (9) :1145-51.|[5]Erdinc Naseri, et al. Proton pump inhibitors omeprazole and lansoprazole induce relaxation of isolated human arteries. Eur J Pharmacol. 2006 Feb 15;531 (1-3) :226-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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CatalogName
A1229-1000Lansoprazole

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