TSI-01

• Target:

  Others|||PAFR

• Related Pathways:

  Others|||GPCR/G Protein

• Purity:

  0.9987

• Bioactivity:

  TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 ?M and 3.02 ?M for human LPCAT2 and LPCAT1, respectively) . At 60 ?M, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages.

• Smiles:

  O=C (OC (C) C) C1=CC=C (C=C1) N2C (=O) C (Cl) =C (Cl) C2=O

• Molecular Formula:

  C14H11Cl2NO4

• Molecular Weight:

  328.15

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  704878-75-1