TSI-01

• Target :

  Others|||PAFR

• Related Pathways :

  Others|||GPCR/G Protein

• Purity :

  0.9987

• Bioactivity :

  TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 ?M and 3.02 ?M for human LPCAT2 and LPCAT1, respectively) . At 60 ?M, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages.

• Smiles :

  O=C(OC(C)C)C1=CC=C(C=C1)N2C(=O)C(Cl)=C(Cl)C2=O

• Molecular Formula :

  C14H11Cl2NO4

• Molecular Weight :

  328.15

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  704878-75-1