TSI-01

CAT: 0931-T24904-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T24904-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

704878-75-1

Target

Others, PAFR

Related Pathways

Others, GPCR/G Protein

Purity

0.9987

Bioactivity

TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 μM and 3.02 μM for human LPCAT2 and LPCAT1, respectively) . At 60 μM, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages.

Smiles

O=C(OC(C)C)C1=CC=C(C=C1)N2C(=O)C(Cl)=C(Cl)C2=O

Molecular Formula

C14H11Cl2NO4

Molecular Weight

328.15

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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