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TSI-01

CAT: 0931-T24904-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T24904-01Size:1 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
704878-75-1
Target
Others|||PAFR
Related Pathways
Others|||GPCR/G Protein
Purity
0.9987
Bioactivity
TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 ?M and 3.02 ?M for human LPCAT2 and LPCAT1, respectively) . At 60 ?M, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages.
Smiles
O=C(OC(C)C)C1=CC=C(C=C1)N2C(=O)C(Cl)=C(Cl)C2=O
Molecular Formula
C14H11Cl2NO4
Molecular Weight
328.15
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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