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Pindolol-d7

CAT: 0804-HY-B0982S-01Size: 2.5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0982S-01Size:2.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pindolol-d7 (LB-46-d7) is the deuterium labeled Pindolol. Pindolol (LB-46) is the antagonist for 5-HT 1A (Ki=33 nM) and 5-HT 1B. Pindolol is the antagonist for β1/β2-adrenergic receptor. Pindolol exhibits anti-anxiety and antidepressant effects[1][2].
CAS Number
1185031-19-9
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O(CC(CNC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])O)C1=C2C(NC=C2)=CC=C1
Molecular Formula
C14H13D7N2O2
Molecular Weight
255.36
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Patkar OL, et al., Pindolol Rescues Anxiety-Like Behavior and Neurogenic Maladaptations of Long-Term Binge Alcohol Intake in Mice. Front Behav Neurosci. 2019 Nov 29;13:264.|[3]Fernandes E, et al., Pindolol is a potent scavenger of reactive nitrogen species. Life Sci. 2005 Sep 2;77 (16) :1983-92.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor

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