Pindolol-d7

• Description :

  Pindolol-d7 (LB-46-d7) is the deuterium labeled Pindolol. Pindolol (LB-46) is the antagonist for 5-HT 1A (Ki=33 nM) and 5-HT 1B. Pindolol is the antagonist for β1/β2-adrenergic receptor. Pindolol exhibits anti-anxiety and antidepressant effects[1][2].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Adrenergic Receptor; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling; Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Neurological Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  O(CC(CNC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])O)C1=C2C(NC=C2)=CC=C1

• Molecular Formula :

  C14H13D7N2O2

• Molecular Weight :

  255.36

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Patkar OL, et al., Pindolol Rescues Anxiety-Like Behavior and Neurogenic Maladaptations of Long-Term Binge Alcohol Intake in Mice. Front Behav Neurosci. 2019 Nov 29;13:264.|[3]Fernandes E, et al., Pindolol is a potent scavenger of reactive nitrogen species. Life Sci. 2005 Sep 2;77 (16) :1983-92.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT1 Receptor

• CAS Number :

  [1185031-19-9]