Pindolol

• Description :

  Pindolol (LB-46) is the antagonist for 5-HT 1A (Ki=33 nM) and 5-HT 1B. Pindolol is the antagonist for β1/β2-adrenergic receptor. Pindolol exhibits anti-anxiety and antidepressant effects[1][2].

• Product Name Alternative :

  LB-46

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  5-HT Receptor; Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Pindolol.html

• Purity :

  99.91

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OC(CNC(C)C)COC1=CC=CC2=C1C=CN2

• Molecular Formula :

  C14H20N2O2

• Molecular Weight :

  248.32

• Precautions :

  H301

• References & Citations :

  [1]Patkar OL, et al., Pindolol Rescues Anxiety-Like Behavior and Neurogenic Maladaptations of Long-Term Binge Alcohol Intake in Mice. Front Behav Neurosci. 2019 Nov 29;13:264.|[2]Fernandes E, et al., Pindolol is a potent scavenger of reactive nitrogen species. Life Sci. 2005 Sep 2;77 (16) :1983-92.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT1 Receptor; mLAG-3

• CAS Number :

  [13523-86-9]