CPI-455 HCl

• Target:

  Histone Demethylase

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  CPI-455 is a specific KDM5 inhibitor with IC50 value of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with targeted agents or standard chemotherapy.

• Smiles:

  Cl.CC (C) c1c ([nH]c2c (cnn2c1=O) C#N) -c1ccccc1

• Molecular Formula:

  C16H15ClN4O

• Molecular Weight:

  314.77

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2095432-28-1