YS-121

• Target:

  Others|||PGE Synthase|||Lipoxygenase

• Related Pathways:

  Metabolism|||Immunology/Inflammation|||Others

• Bioactivity:

  YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 ?M) and 5-lipoxygenase (5-LOX; IC50=6.5 ?M) . YS121 dose-dependently reduces the production of PGE2 with EC50=12 ?M in IL-1?-stimulated A549 cells [1].

• Smiles:

  N(C1=NC(SC(CCCCCC)C(O)=O)=NC(Cl)=C1)C2=C(C)C(C)=CC=C2

• Molecular Formula:

  C20H26ClN3O2S

• Molecular Weight:

  407.96

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  916482-17-2