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UMB-32

CAT: 0931-T21920-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T21920-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1635437-39-6
Target
Epigenetic Reader Domain, Others
Related Pathways
Chromatin/Epigenetic, Others
Bioactivity
UMB-32 is a potent and selective BRD4 inhibitor, demonstrating an affinity for BRD4 with a dissociation constant (K d) of 550 nM and an inhibitory concentration 50 (IC 50) of 637 nM. Moreover, UMB-32 exhibits effectiveness against TAF1, a bromodomain-containing transcription factor [1].
Smiles
N(C(C)(C)C)C1=C(N=C2N1C=CN=C2)C3=CC=C(C=C3)C=4C(C)=NOC4C
Molecular Formula
C21H23N5O
Molecular Weight
361.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-Tert-Butyl-2-[4-(3,5-Dimethyl-1,2-Oxazol-4-Yl)phenyl]imidazo[1,2-A]pyrazin-3-Amine
CAS Number1635437-39-6
PubChem CID86208116
IUPAC NameN-tert-butyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]imidazo[1,2-a]pyrazin-3-amine
Molecular FormulaC21H23N5O
Molecular Weight361.4
XLogP4.5
Topological Polar Surface Area68.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity501
SMILES
CC1=C(C(=NO1)C)C2=CC=C(C=C2)C3=C(N4C=CN=CC4=N3)NC(C)(C)C
InChI
InChI=1S/C21H23N5O/c1-13-18(14(2)27-25-13)15-6-8-16(9-7-15)19-20(24-21(3,4)5)26-11-10-22-12-17(26)23-19/h6-12,24H,1-5H3
InChIKey
YXPVTKHEWGXKEY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-Tert-Butyl-2-[4-(3,5-Dimethyl-1,2-Oxazol-4-Yl)phenyl]imidazo[1,2-A]pyrazin-3-Amine
CAS: 1635437-39-6
CID: 86208116
Formula: C21H23N5O
MW: 361.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight361.4
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass361.19026037
Monoisotopic Mass361.19026037
Topological Polar Surface Area68.3 Ų
Heavy Atom Count27
Formal Charge0
Complexity501
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
C4229-5UMB-32
A24405-50UMB-32 50mg
A24405-10UMB-32 10mg
A24405-5UMB-32 5mg
A24405-1UMB-32 1mg
GTR19200357-01UMB-136
531499UMB-68 sodium
144382Connexin 32 (Connexin-32)
sc-59948Connexin 32 (CXN-32)
B2702-07Brain Natriuretic Peptide 32 (BNP-32) (10-32) (rat) (BNP-32)

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