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Prostratin

CAT: 0931-T21441-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0931-T21441-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
60857-08-1
Target
PKC, Kras, NF-κB, HIV Protease, Ras
Related Pathways
Proteases/Proteasome, NF-κB, Chromatin/Epigenetic, Cytoskeletal Signaling, MAPK, Microbiology/Virology, GPCR/G Protein
Bioactivity
Prostratin (12-Deoxyphorbol-13-acetate) is an orally active protein kinase C (PKC) activator with a Ki value of 12.5 nM.As an NF-κB activator, Prostratin activates HIV gene expression in T cells.Prostratin inhibits the growth of acute myeloid leukemia (AML) cell lines and enhances cytarabine-induced AML cell differentiation. In addition, Prostratin induced KRAS phosphorylation and inhibited the growth of KRAS-mutated tumors.
Smiles
O(C(C)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)C2)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]
Molecular Formula
C22H30O6
Molecular Weight
390.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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