Prostratin

• Target:

  PKC|||Kras|||NF-?B|||HIV Protease|||Ras

• Related Pathways:

  Proteases/Proteasome|||NF-?B|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||MAPK|||Microbiology/Virology|||GPCR/G Protein

• Bioactivity:

  Prostratin (12-Deoxyphorbol-13-acetate) is an orally active protein kinase C (PKC) activator with a Ki value of 12.5 nM.As an NF-?B activator, Prostratin activates HIV gene expression in T cells.Prostratin inhibits the growth of acute myeloid leukemia (AML) cell lines and enhances cytarabine-induced AML cell differentiation. In addition, Prostratin induced KRAS phosphorylation and inhibited the growth of KRAS-mutated tumors.

• Smiles:

  O (C (C) =O) [C@@]12[C@@] (C1 (C) C) ([C@]3 ([C@] (O) ([C@H] (C) C2) [C@]4 ([C@] (O) (CC (CO) =C3) C (=O) C (C) =C4) [H]) [H]) [H]

• Molecular Formula:

  C22H30O6

• Molecular Weight:

  390.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  60857-08-1