MK-0731

• Target:

  Others|||Apoptosis|||Kinesin|||Lipoxygenase

• Related Pathways:

  Cytoskeletal Signaling|||Metabolism|||Apoptosis|||Others

• Bioactivity:

  MK-0731, a synthetic small molecule with potential antineoplastic activity, selectively inhibits kinesin spindle protein (KSP), leading to the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase and apoptosis in tumor cells that overexpress KSP.

• Smiles:

  C (O) [C@@]1 (N (C (N (C) [C@@H]2[C@H] (F) CN (C) CC2) =O) CC (=C1) C3=C (F) C=CC (F) =C3) C4=CC=CC=C4

• Molecular Formula:

  C25H28F3N3O2

• Molecular Weight:

  459.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  845256-65-7