SB 224289

• Target:

  Others|||5-HT Receptor

• Related Pathways:

  GPCR/G Protein|||Neuroscience|||Others

• Bioactivity:

  SB 224289 is a selective antagonist of 5-HT1B receptor with pKi of 8.2. It is a centrally active following oral administration in vivo. SB 224289 displays 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays.

• Smiles:

  C (=O) (N1C=2C=C3C4 (COC3=CC2CC1) CCN (C) CC4) C5=CC=C (C=C5) C6=C (C) C=C (C=C6) C=7N=C (C) ON7

• Molecular Formula:

  C32H32N4O3

• Molecular Weight:

  520.62

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  180083-23-2