NBD-14189

CAT: 0804-HY-139985-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-139985-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
NBD-14189 is a potent HIV-1 entry antagonist with an IC50 of 89 nM against the HIV-1HXB2 pseudovirus. NBD-14189 binds to HIV-1 gp120 and shows potent antiviral activity (EC50[1][2].
CAS Number
[2234273-72-2]
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nbd-14189.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(C(F)(F)F)C=CC(C2=CC=C(C(N[C@@H](CN)C3=NC(CO)=CS3)=O)N2)=C1
Molecular Formula
C18H16F4N4O2S
Molecular Weight
428.40
References & Citations
[1]Francesca Curreli, et al. Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120. Eur J Med Chem. 2018 Jun 25;154:367-391.|[2]Natalie Losada, et al. HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites. J Med Chem. 2021 Nov 25;64 (22) :16530-16540.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

Related Products

CatalogName
HY-139989-01NBD-14270
HY-130433NBD Sphingosine
HY-P10839NBD peptide
HY-123067-01NBD-Fructose
HY-149903NBD-sphinganine
HY-76648-01NBD-556
HY-76649-01NBD-557
HY-D0042-01NBD-Cl
HY-W015012-01NBD-Hydrazine
HY-129109-01NBD-Pen

Alternative Products

CatalogName
BA1964-1NBD-14189
BUP18438-01NBD-Cl
24113-61NBD Chloride
LI-013NBD-FPP
#60025NBD-DHPE
MBS5783145NBD-Pen
MBS386820-01NBD-557
M11804-01NBD-11021
C01409NBD-556
MF-0115562-01NBD-Hydrazine

Popular Products