Cyclic ADP-​ribose

• UNSPSC Description:

  Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1][2][3].

• Target Antigen:

  Calcium Channel; Endogenous Metabolite; TRP Channel

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Infection; Endocrinology; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/cyclic-adp-ribose.html

• Purity:

  96.0

• Solubility:

  H2O : 5 mg/mL (ultrasonic;warming)

• Smiles:

  O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N(C=N3)[C@@H]([C@H](O)[C@@H]4O)O[C@@H]4CO5)=N)O[C@@H]1COP(OP5(O)=O)(O)=O

• Molecular Weight:

  541.30

• References & Citations:

  [1]Ribeiro JM, et al. Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase. Sci Rep. 2018 Jan 18;8(1):1036.|[2]Galione A, et, al. Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science. 1991 Sep 6;253(5024):1143-6.|[3]Lee HC, et, al. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity. J Biol Chem. 1989 Jan 25;264(3):1608-15.|[4]Verderio C, et, al. Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes. J Neurochem. 2001 Aug;78(3):646-57.|[5]Zhong J, et, al. Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. Front Neurosci. 2016 Jul 22;10:304.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  -80°C

• Clinical Information:

  No Development Reported

• CAS Number:

  119340-53-3