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UNC0321

CAT: 0931-T17204-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T17204-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1238673-32-9
Target
Histone Methyltransferase, Apoptosis, Glucagon Receptor
Related Pathways
GPCR/G Protein, Apoptosis, Chromatin/Epigenetic
Purity
0.998
Bioactivity
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.
Smiles
COc1cc2c(NC3CCN(C)CC3)nc(nc2cc1OCCOCCN(C)C)N1CCCN(C)CC1
Molecular Formula
C27H45N7O3
Molecular Weight
515.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Unc0321

7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine is a member of quinazolines.

CAS Number1238673-32-9
PubChem CID46901937
IUPAC Name7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Molecular FormulaC27H45N7O3
Molecular Weight515.7
XLogP2.9
Topological Polar Surface Area78.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Heavy Atom Count37
Formal Charge0
Complexity651
SMILES
CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCOCCN(C)C
InChI
InChI=1S/C27H45N7O3/c1-31(2)15-16-36-17-18-37-25-20-23-22(19-24(25)35-5)26(28-21-7-11-33(4)12-8-21)30-27(29-23)34-10-6-9-32(3)13-14-34/h19-21H,6-18H2,1-5H3,(H,28,29,30)
InChIKey
AULLUGALUBVBDD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Unc0321
CAS: 1238673-32-9
CID: 46901937
Formula: C27H45N7O3
MW: 515.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight515.7
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Exact Mass515.35838832
Monoisotopic Mass515.35838832
Topological Polar Surface Area78.5 Ų
Heavy Atom Count37
Formal Charge0
Complexity651
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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A13200-1UNC0321 1mg
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