PIN1 inhibitor API-1

CAT: 0931-MF-0012767-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0012767-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
680622-70-2
Target
MicroRNA
Related Pathways
Chromatin/Epigenetic
Purity
0.9848
Bioactivity
PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM) that retains the active conformation of pXPO5, restoring its ability to transport pre-miRNAs from the nucleus to the cytoplasm, thereby up-regulating anticancer miRNA biogenesis to suppress hepatocellular carcinoma development both in vitro and in vivo. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain, effectively inhibiting Pin1 cis-trans isomerizing activity.
Smiles
Nc1nc(OCc2ccc(CNC(=O)C(F)(F)F)cc2)c2[nH]cnc2n1
Molecular Formula
C15H13F3N6O2
Molecular Weight
366.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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