API-1

• Target :

  Apoptosis|||PARP|||Caspase|||Akt

• Related Pathways :

  Cytoskeletal Signaling|||Proteases/Proteasome|||Chromatin/Epigenetic|||Apoptosis|||DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling

• Purity :

  0.9907

• Bioactivity :

  API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, ?-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .

• Smiles :

  NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c2c1=O

• Molecular Formula :

  C13H15N5O6

• Molecular Weight :

  337.29

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  36707-00-3