PF-06459988

• Target:

  EGFR

• Related Pathways:

  Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis

• Purity:

  0.98

• Bioactivity:

  PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor. PF-06459988 has high efficiency and high affinity for EGFRs double mutants containing T790M, and has minimal activity against WT EGFR. PF-06459988 makes a candidate drug for the treatment of cancer.

• Smiles:

  CO[C@H]1CN (C[C@@H]1COc1nc (Nc2cnn (C) c2) nc2[nH]cc (Cl) c12) C (=O) C=C

• Molecular Formula:

  C19H22ClN7O3

• Molecular Weight:

  431.88

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1428774-45-1