PF-06459988

• CAS Number :

  1428774-45-1

• Target :

  EGFR

• Related Pathways :

  Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis

• Purity :

  0.98

• Bioactivity :

  PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor. PF-06459988 has high efficiency and high affinity for EGFRs double mutants containing T790M, and has minimal activity against WT EGFR. PF-06459988 makes a candidate drug for the treatment of cancer.

• Smiles :

  CO[C@H]1CN(C[C@@H]1COc1nc(Nc2cnn(C)c2)nc2[nH]cc(Cl)c12)C(=O)C=C

• Molecular Formula :

  C19H22ClN7O3

• Molecular Weight :

  431.88

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C