PF-06380101

• Target:

  Microtubule Associated|||ADC Cytotoxin

• Related Pathways:

  Antibody-drug Conjugate/ADC Related|||Cytoskeletal Signaling

• Bioactivity:

  PF-06380101 is an auristatin microtubule inhibitor and is a cytotoxic Dolastatin 10 analogue. When compared to other synthetic auristatin analogues that are used in the preparation of ADCs, PF-06380101 displays excellent potencies in tumor cell proliferation assays and differential ADME properties.

• Smiles:

  CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C

• Molecular Formula:

  C39H62N6O6S

• Molecular Weight:

  743.01

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1436391-86-4