NI-42

• Target:

  Epigenetic Reader Domain

• Related Pathways:

  Chromatin/Epigenetic

• Purity:

  0.9918

• Bioactivity:

  NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) . It also has excellent selectivity over nonclass IV BRD proteins.

• Smiles:

  Cc1cc2cc(NS(=O)(=O)c3ccc(cc3)C#N)ccc2n(C)c1=O

• Molecular Formula:

  C18H15N3O3S

• Molecular Weight:

  353.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1884640-99-6