M-525

• Target :

  Epigenetic Reader Domain|||Others

• Related Pathways :

  Chromatin/Epigenetic|||Others

• Bioactivity :

  M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL protein-protein interaction inhibitor. It has an Anti-leukemia activity.

• Smiles :

  [C@@](C#N)([C@@]1([C@@H](NC(OC)=O)CCC1)[H])(C2=CC(F)=CC=C2)[C@H]3CCN(CC4CN(C4)C5=CC=C(S(=O)(=O)C6CN(C(/C=C/CN(C)C)=O)C6)C=C5)CC3

• Molecular Formula :

  C39H51FN6O5S

• Molecular Weight :

  734.92

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2173582-08-4