M-525

CAT: 0804-HY-124069Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-124069Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M-525 is a first-in-class, highly potent, irreversible and covalent menin-MLL protein-protein interaction inhibitor. M-525 binds to menin with an IC50 of 3 nM and achieves low nanomolar potencies in cell growth inhibition and in suppression of MLL regulated gene expression in MLL leukemia cells. Anti-leukemia activity[1].
CAS Number
[2173582-08-4]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m-525.html
Solubility
10 mM in DMSO
Smiles
O=C(OC)N[C@@H]1[C@@H]([C@](C2CCN(CC3CN(C4=CC=C(S(=O)(C5CN(C(/C=C/CN(C)C)=O)C5)=O)C=C4)C3)CC2)(C#N)C6=CC=CC(F)=C6)CCC1
Molecular Formula
C39H51FN6O5S
Molecular Weight
734.92
References & Citations
[1]Xu S, et al. Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl. 2018 Feb 5;57 (6) :1601-1605.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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