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LY 178002

CAT: 0931-T15825-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T15825-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
107889-32-7
Target
Phospholipase, Retinoid Receptor, Lipoxygenase, COX
Related Pathways
Neuroscience, Immunology/Inflammation, Metabolism
Bioactivity
LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase) . LY 178002 also inhibits cellular production of LTB4 by human polymorphonuclear leukocytes and displays relatively weak inhibition on cyclooxygenase.
Smiles
C(C)(C)(C)C1=C(O)C(C(C)(C)C)=CC(C=C2C(=O)NCS2)=C1
Molecular Formula
C18H25NO2S
Molecular Weight
319.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

LY 178002

phospholipase A2 inhibitor; inhibits leukotriene B4 production

CAS Number107889-32-7
PubChem CID6439155
IUPAC Name(5Z)-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
Molecular FormulaC18H25NO2S
Molecular Weight319.5
XLogP5.2
Topological Polar Surface Area74.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity435
SMILES
CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)/C=C\2/C(=O)NCS2
InChI
InChI=1S/C18H25NO2S/c1-17(2,3)12-7-11(9-14-16(21)19-10-22-14)8-13(15(12)20)18(4,5)6/h7-9,20H,10H2,1-6H3,(H,19,21)/b14-9-
InChIKey
BUDGLLLMROWLOB-ZROIWOOFSA-N
Chemical Structure
2D Structure
2D structure of LY 178002
CAS: 107889-32-7
CID: 6439155
Formula: C18H25NO2S
MW: 319.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight319.5
XLogP35.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass319.16060021
Monoisotopic Mass319.16060021
Topological Polar Surface Area74.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity435
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
A19333-10LY 178002 10mg
A19333-50LY 178002 50mg
HY-101579-01LY 178002
A19333-5LY 178002 5mg
A19333-100LY 178002 100mg
A19333-25LY 178002 25mg
A19333-1LY 178002 1mg

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