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LY-2624587

CAT: 0931-T9901A-1919-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T9901A-1919-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2125546-89-4
Target
Akt, p38 MAPK, Apoptosis, CXCR
Related Pathways
Cytoskeletal Signaling, Apoptosis, PI3K/Akt/mTOR signaling, Autophagy, GPCR/G Protein, MAPK, Immunology/Inflammation
Bioactivity
LY-2624587 is a humanized IgG4 monoclonal antibody antagonist targeting CXCR4. It effectively blocks the interaction between SDF-1 and CXCR4, as well as SDF-1-induced GTP binding. LY-2624587 significantly inhibits cellular migration and induces apoptosis in human lymphoma and leukemia cells. Additionally, LY-2624587 suppresses cell signaling mediated by CXCR4 and SDF-1, including MAPK and AKT activation. This compound is utilized in research on human hematological malignancies, such as acute myeloid leukemia (AML) .
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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