K-252b

CAT: 0931-T15637-01Size: 500 µgDry Ice: NoHazardous: No

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CAT#:0931-T15637-01Size:500 µg

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CAS Number

99570-78-2

Target

PKC

Related Pathways

Chromatin/Epigenetic, Cytoskeletal Signaling

Bioactivity

K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor. It is effective in inhibiting extracellular kinases in cultured cells due to its inability to freely cross the cell membrane.

Smiles

CC12OC(CC1(O)C(O)=O)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13

Molecular Formula

C26H19N3O5

Molecular Weight

453.45

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

K-252b

K-252b is an indolocarbazole.

CAS Number	99570-78-2
PubChem CID	9981344
IUPAC Name	(15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylic acid
Molecular Formula	C26H19N3O5
Molecular Weight	453.4
XLogP	2.4
Topological Polar Surface Area	106
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Heavy Atom Count	34
Formal Charge	0
Complexity	961

SMILES

C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O

InChI

InChI=1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1

InChIKey

AMSOPBXQXSAAAC-PLZPTFKGSA-N

Chemical Structure

2D Structure

CAS: 99570-78-2

CID: 9981344

Formula: C26H19N3O5

MW: 453.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	453.4
XLogP3	2.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	453.13247072
Monoisotopic Mass	453.13247072
Topological Polar Surface Area	106 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	961
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T15638-01	K-252c
T15636	K-252a
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T204123-01	K-8794
TN8081-01	Marsdenoside K
TN7859-01	Cyclocarioside K
TN11064-01	Harzianol K
TN10787-01	Polyoxin K
TN10729-01	Thaigranatumin K
T25563	K 41

Alternative Products

Catalog	Name
MBS565506-01	K-252b
AM025C	MIRacleTM isc-miR-252b miRNA Agomir/Antagomir
RM-Z240000-01	S-Antcin K; Zhankuic acid K
GTR19066420-01	R-K-R-A-R-K-E
MBS1070614-01	Recombinant Escherichia coli Protein K (K)
8000124	Proteinase K (contains Proteinase K solution)
351334-01	KRAS (GTPase Kras, C-K-RAS, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, NS3, RASK2, GTPase Kras, K-RAS2A, K RAS2B, K RAS4A, K RAS4B, KI RAS, KRAS 1, NS 3)
P6803	PDuRCC-K
BIO-37039	Proteinase K
HY-N15509	Harzianol K

K-252b

Chemical Information

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