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HFI-142

CAT: 0931-T15479-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T15479-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
332164-34-8
Target
Others, Aminopeptidase
Related Pathways
Metabolism, Others
Bioactivity
HFI-142 is a small-molecule inhibitor that binds specifically to the active site of aminopeptidase N and suppresses its enzymatic activity. HFI-142 has been demonstrated to inhibit leukotriene A4 biosynthesis in red blood cells, an effect that may offer therapeutic potential for the research in cancer by modulating inflammatory and metabolic pathways implicated in tumor growth and progression. HFI-142 was also shown to inhibit the activity of additional aminopeptidases, including aminopeptidase N, as well as other enzymes associated with protein metabolism.
Smiles
O=C(OCC)C1=C(OC2=CC(O)=CC=C2C1C=3C=NC=CC3)N
Molecular Formula
C17H16N2O4
Molecular Weight
312.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

ethyl 2-amino-7-hydroxy-4-(pyridin-3-yl)-4H-chromene-3-carboxylate
CAS Number332164-34-8
PubChem CID655457
IUPAC Nameethyl 2-amino-7-hydroxy-4-pyridin-3-yl-4H-chromene-3-carboxylate
Molecular FormulaC17H16N2O4
Molecular Weight312.32
XLogP2.4
Topological Polar Surface Area94.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity479
SMILES
CCOC(=O)C1=C(OC2=C(C1C3=CN=CC=C3)C=CC(=C2)O)N
InChI
InChI=1S/C17H16N2O4/c1-2-22-17(21)15-14(10-4-3-7-19-9-10)12-6-5-11(20)8-13(12)23-16(15)18/h3-9,14,20H,2,18H2,1H3
InChIKey
JOPNHSIHFSZJMB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of ethyl 2-amino-7-hydroxy-4-(pyridin-3-yl)-4H-chromene-3-carboxylate
CAS: 332164-34-8
CID: 655457
Formula: C17H16N2O4
MW: 312.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight312.32
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass312.11100700
Monoisotopic Mass312.11100700
Topological Polar Surface Area94.7 Ų
Heavy Atom Count23
Formal Charge0
Complexity479
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HNA16434-01HFI-142
A19709-100HFI-142 100mg
A19709-10HFI-142 10mg
A19709-50HFI-142 50mg
A19709-5HFI-142 5mg
A19709-2HFI-142 2mg
A19709-25HFI-142 25mg
A19709-10mM-DHFI-142 10mM * 1mL in DMSO
HY-160239-01HFI-437
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