Gemcitabine elaidate

CAT: 0931-MF-0032915-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0032915-01Size:2 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
210829-30-4
Target
Autophagy|||Nucleoside Antimetabolite/Analog|||Apoptosis
Related Pathways
Cell Cycle/Checkpoint|||Apoptosis|||DNA Damage/DNA Repair|||Autophagy
Bioactivity
Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
Smiles
CCCCCCCC\C=C\CCCCCCCC(=O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1O
Molecular Formula
C27H43F2N3O5
Molecular Weight
527.64
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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