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Gemcitabine (elaidate)

CAT: 0013-GTR19156279-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156279-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gemcitabine elaidate, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
CAS Number
210829-30-4
Product Name Alternative
CP-4126 | CO-101 | Gemcitabine 5'-elaidate
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:26 mg/mL (49.28 mM) ; H2O:< 0.1 mg/mL (insoluble)
Smiles
CCCCCCCC/C=C/CCCCCCCC (OC[C@H]1O[C@@H] (N2C=CC (N) =NC2=O) C (F) (F) [C@@H]1O) =O
Molecular Formula
C27H43F2N3O5
Molecular Weight
527.64
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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