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EF-5

CAT: 0931-T15202-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T15202-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
152721-37-4
Target
Others
Related Pathways
Others
Purity
0.9826
Bioactivity
EF-5 (2-Nitroimidazole) is a agent of hypoxia labeling. It is used to identify hypoxia in cells.
Smiles
[O-][N+](=O)c1nccn1CC(=O)NCC(F)(F)C(F)(F)F
Molecular Formula
C8H7F5N4O3
Molecular Weight
302.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide

EF5 is a fluorinated derivative of the 2-nitroimidazole etanidazole. EF5 is effective in accessing oxygen levels in tumor tissue through its adduct formation to intracellular macromolecules in the absence of oxygen. Reduction of this agent is carried out by a diverse group of enzymes in the cytoplasm, microsomes and mitochondria. Tissue hypoxia detection via EF5 has been reported in several cancers, including squamous cell carcinoma of the cervix and the head and neck, and in sarcoma.

CAS Number152721-37-4
PubChem CID389053
IUPAC Name2-(2-nitroimidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide
Molecular FormulaC8H7F5N4O3
Molecular Weight302.16
XLogP1.1
Topological Polar Surface Area92.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity383
SMILES
C1=CN(C(=N1)[N+](=O)[O-])CC(=O)NCC(C(F)(F)F)(F)F
InChI
InChI=1S/C8H7F5N4O3/c9-7(10,8(11,12)13)4-15-5(18)3-16-2-1-14-6(16)17(19)20/h1-2H,3-4H2,(H,15,18)
InChIKey
JGGDSDPOPRWSCX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide
CAS: 152721-37-4
CID: 389053
Formula: C8H7F5N4O3
MW: 302.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight302.16
XLogP31.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass302.04383091
Monoisotopic Mass302.04383091
Topological Polar Surface Area92.7 Ų
Heavy Atom Count20
Formal Charge0
Complexity383
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS3615292-01EF-5
sc-393731EF-1 δ (A-5)
HY-U00118R-01EF-5 (Standard)
sc-393924EF-Tu (A-5)
sc-393924 HRPEF-Tu (A-5) HRP
sc-393731 HRPEF-1 δ (A-5) HRP
sc-393924 ACEF-Tu (A-5) AC
sc-393924 FITCEF-Tu (A-5) FITC
sc-393731 PEEF-1 δ (A-5) PE
sc-393924 PEEF-Tu (A-5) PE

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