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Dipraglurant

CAT: 0931-T15134-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T15134-02Size:5 mg
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CAS Number
872363-17-2
Target
GluR
Related Pathways
Neuroscience
Purity
0.987
Bioactivity
Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model.
Smiles
Fc1ccc2nc(CCC#Cc3ccccn3)cn2c1
Molecular Formula
C16H12FN3
Molecular Weight
265.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Dipraglurant

Dipraglurant has been used in trials studying the treatment of Parkinson's Disease. It is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM).

CAS Number872363-17-2
PubChem CID44557636
IUPAC Name6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine
Molecular FormulaC16H12FN3
Molecular Weight265.28
XLogP3.5
Topological Polar Surface Area30.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity386
SMILES
C1=CC=NC(=C1)C#CCCC2=CN3C=C(C=CC3=N2)F
InChI
InChI=1S/C16H12FN3/c17-13-8-9-16-19-15(12-20(16)11-13)7-2-1-5-14-6-3-4-10-18-14/h3-4,6,8-12H,2,7H2
InChIKey
LZXMUJCJAWVHPZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dipraglurant
CAS: 872363-17-2
CID: 44557636
Formula: C16H12FN3
MW: 265.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight265.28
XLogP33.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass265.10152556
Monoisotopic Mass265.10152556
Topological Polar Surface Area30.2 Ų
Heavy Atom Count20
Formal Charge0
Complexity386
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A3366-5Dipraglurant
A11382-25Dipraglurant 25mg
A11382-5Dipraglurant 5mg
A11382-1Dipraglurant 1mg
A11382-100Dipraglurant 100mg
A11382-50Dipraglurant 50mg
A11382-10Dipraglurant 10mg
A11382-10mM-DDipraglurant 10mM * 1mL in DMSO

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