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Dipraglurant

CAT: 0804-HY-14859-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14859-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dipraglurant (ADX48621) is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo[1][2]. Dipraglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
872363-17-2
Product Name Alternative
ADX48621
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Dipraglurant.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : ≥ 40 mg/mL
Smiles
FC1=CN2C(C=C1)=NC(CCC#CC3=NC=CC=C3)=C2
Molecular Formula
C16H12FN3
Molecular Weight
265.29
References & Citations
[1]Bezard E, et, al. The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model. Mov Disord. 2014 Jul;29 (8) :1074-9.|[2]Sciamanna G, et, al. Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia. Neuropharmacology. 2014 Oct;85:440-50.|[3]The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
MGluR5

Alternative Products

CatalogName
A3366-5Dipraglurant
A11382-25Dipraglurant 25mg
A11382-5Dipraglurant 5mg
A11382-1Dipraglurant 1mg
A11382-100Dipraglurant 100mg
A11382-50Dipraglurant 50mg
A11382-10Dipraglurant 10mg
A11382-10mM-DDipraglurant 10mM * 1mL in DMSO

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