BMS-906024

• Target:

  Gamma-secretase

• Related Pathways:

  Proteases/Proteasome|||Neuroscience|||Stem Cells

• Purity:

  >99.99%

• Bioactivity:

  BMS-906024 (Osugacestat) is an orally available and selective inhibitor of ?-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.

• Smiles:

  CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C1=O)c1ccccc1

• Molecular Formula:

  C26H26F6N4O3

• Molecular Weight:

  556.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1401066-79-2