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BMS-906024

CAT: 0931-T14680-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T14680-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1401066-79-2
Target
Gamma-secretase
Related Pathways
Proteases/Proteasome, Neuroscience, Stem Cells
Purity
>99.99%
Bioactivity
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.
Smiles
CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C1=O)c1ccccc1
Molecular Formula
C26H26F6N4O3
Molecular Weight
556.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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BA8533-1BMS-906024
BB162475BMS 906024
A21172-25BMS-906024 25mg
A21172-2BMS-906024 2mg
A21172-50BMS-906024 50mg
A21172-10BMS-906024 10mg
A21172-5BMS-906024 5mg
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A21172-100BMS-906024 100mg
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