BMS-509744

• Target :

  Others|||IL Receptor|||HIV Protease|||Immunology/Inflammation related|||Tyrosine Kinases

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Microbiology/Virology|||Proteases/Proteasome|||Others|||Immunology/Inflammation

• Purity :

  0.997

• Bioactivity :

  BMS-509744 is a selective, ATP-competitive Itk inhibitor with an IC50 of 19 nM. It inhibits IL-8 expression and HIV infection, ameliorates pulmonary inflammation in allergic asthma mouse models, and reduces Imiquimod-induced skin inflammation in mice.

• Smiles :

  O=C(NC1=NC=C(S1)SC2=CC(=C(OC)C=C2C)C(=O)N3CCN(C(=O)C)CC3)C4=CC=C(C=C4)CNC(C)C(C)(C)C

• Molecular Formula :

  C32H41N5O4S2

• Molecular Weight :

  623.83

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  439575-02-7