AZD0424

CAT: 0931-T14370-01Size: 25 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T14370-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

692054-06-1

Target

Bcr-Abl, Apoptosis, Src, Others

Related Pathways

Others, Tyrosine Kinase/Adaptors, Apoptosis, Cytoskeletal Signaling, Angiogenesis

Bioactivity

AZD0424, an orally active compound characterized as a dual selective Src/Abl kinase inhibitor, exhibits potential antineoplastic activity[1] and promotes apoptosis and cell cycle arrest in lymphoma cells[2].

Smiles

N(C=1C=2C(OC(C)C)=CC(OCCN3CCN(C(C)=O)CC3)=CC2N=CN1)C4=C5C(=NC=C4Cl)OCO5

Molecular Formula

C25H29ClN6O5

Molecular Weight

528.99

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Azd-0424

AZD0424 has been used in trials studying the treatment of Advanced Solid Tumours.

CAS Number	692054-06-1
PubChem CID	9893171
IUPAC Name	1-[4-[2-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-5-propan-2-yloxyquinazolin-7-yl]oxyethyl]piperazin-1-yl]ethanone
Molecular Formula	C25H29ClN6O5
Molecular Weight	529.0
XLogP	3.2
Topological Polar Surface Area	111
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	8
Heavy Atom Count	37
Formal Charge	0
Complexity	759

SMILES

CC(C)OC1=CC(=CC2=C1C(=NC=N2)NC3=C4C(=NC=C3Cl)OCO4)OCCN5CCN(CC5)C(=O)C

InChI

InChI=1S/C25H29ClN6O5/c1-15(2)37-20-11-17(34-9-8-31-4-6-32(7-5-31)16(3)33)10-19-21(20)24(29-13-28-19)30-22-18(26)12-27-25-23(22)35-14-36-25/h10-13,15H,4-9,14H2,1-3H3,(H,27,28,29,30)

InChIKey

MVWATCATLSSVBH-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 692054-06-1

CID: 9893171

Formula: C25H29ClN6O5

MW: 529.0

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	529.0
XLogP3	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	8
Exact Mass	528.1887957
Monoisotopic Mass	528.1887957
Topological Polar Surface Area	111 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	759
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T204084-01	AZD0022
T14373-01	AZD2423
T14381-01	AZD7624
T201366-01	AZD8421
T14377-01	AZD5423

Alternative Products

Catalog	Name
SCB05406-01	AZD0424
A19488-1	AZD0424 1mg
A19488-100	AZD0424 100mg
A19488-50	AZD0424 50mg
A19488-10	AZD0424 10mg
A19488-25	AZD0424 25mg
A19488-5	AZD0424 5mg

AZD0424

Chemical Information

Related Products

Alternative Products

Popular Products