AY 9944

• Target:

  Others

• Related Pathways:

  Others

• Purity:

  0.9965

• Bioactivity:

  AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol ?7-reductase (DHCR7) enzyme (IC50=13 nM) . At high doses, AY 9944 also inhibits sterol ?7-?8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3?-ol[1][2][3]. Additionally, AY 9944 causes hypocholesterolemia and accumulation of 7DHC.

• Smiles:

  Cl.Cl.Clc1ccccc1CNC[C@H]1CC[C@H](CNCc2ccccc2Cl)CC1

• Molecular Formula:

  C22H30Cl4N2

• Molecular Weight:

  464.3

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  366-93-8