AY 254

• Target :

  Protease-activated Receptor

• Related Pathways :

  GPCR/G Protein

• Bioactivity :

  AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release) . Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.

• Smiles :

  C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C1CCCCC1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O|@@:25|

• Molecular Formula :

  C30H49N9O6

• Molecular Weight :

  631.779

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2093408-03-6