7?,25-Dihydroxycholesterol

• Target :

  Endogenous Metabolite|||EBI2/GPR183

• Related Pathways :

  Metabolism|||GPCR/G Protein

• Bioactivity :

  7?,25-dihydroxycholesterol (7?,25-OHC) is a potent and selective agonist, as well as an endogenous ligand, of the orphan GPCR receptor EBI2 (GPR183) . It serves as a chemokine directing the migration of B cells, T cells, and dendritic cells and exhibits high potency in activating EBI2 (EC50=140 pM; Kd=450 pM) [1][2].

• Smiles :

  C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

• Molecular Formula :

  C27H46O3

• Molecular Weight :

  418.65

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  64907-22-8