Products for Research Use Only
RegisterLogin

(+) -Cevimeline hydrochloride hemihydrate

CAT: 0931-T13460-01Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T13460-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Others, AChR
Related Pathways
Others, Neuroscience
Bioactivity
(+) -Cevimeline hydrochloride hemihydrate ((+) -SNI-2011), a potent muscarinic receptor agonist, shows promise as a therapeutic candidate for xerostomia in Sjogren's syndrome. It exhibits a broad pharmacological profile across various systems in animal models including mice, rats, guinea pigs, rabbits, and dogs. Metabolism studies using rat and dog liver microsomes reveal rapid absorption with peak plasma concentrations (Cmax) within one hour post-oral administration and a half-life (t1/2) between 0.4 to 1.1 hours. Bioavailability is 50% in rats and 30% in dogs. Metabolic analysis shows species-specific differences: rats produce S- and N-oxidized metabolites, while dogs produce only N-oxidized metabolites. Sex-based pharmacokinetic differences were noted in rats but not in dogs. In vitro studies indicate cytochrome P450 (CYP) and flavin-containing monooxygenase (FMO) involvement in the sulfoxidation and N-oxidation of SNI-2011, with CYP2D and CYP3A mainly responsible for sulfoxidation in rat liver microsomes.
Smiles
C[C@H](SC1)O[C@]21CN3CCC2CC3.Cl.[0.5H2O]
Molecular Formula
C10H19ClNO1.5S
Molecular Weight
244.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T20131Cevimeline hydrochloride
T29681-01Trans-Cevimeline hydrochloride
T1636L-01Paroxetine hydrochloride hemihydrate
T71178-01Nafagrel hydrochloride hemihydrate
T8757-01R-Lorcaserin hydrochloride hemihydrate
T21119Cevimeline
T69796-01Nevirapine hemihydrate
T211752-01Enozertinib hemihydrate
T72321-01AZ13705339 hemihydrate
T1782L-01Canagliflozin hemihydrate

Alternative Products

CatalogName
A3300-10Cevimeline hydrochloride hemihydrate
HY-76772B-01(-) -Cevimeline (hydrochloride hemihydrate)
HY-76772-01Cevimeline (hydrochloride hemihydrate)
HY-76772A-01(+) -Cevimeline (hydrochloride hemihydrate)
MBS5754207(+)-Cevimeline hydrochloride hemihydrate
MBS5754174(-)-Cevimeline hydrochloride hemihydrate
GTR19204529-01(-) -Cevimeline hydrochloride hemihydrate
GTR19204499-01(+) -Cevimeline hydrochloride hemihydrate
HY-76772R-01Cevimeline (hydrochloride hemihydrate) (Standard)
A15042-10Cevimeline hydrochloride hemihydrate 10mg

Popular Products