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ZK-261991

CAT: 0931-T13402-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T13402-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
886563-25-3
Target
VEGFR, HIF
Related Pathways
Chromatin/Epigenetic, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase (IC50 of 5 nM, VEGFR2) .
Smiles
N(C(=O)C1=C(NCC=2C=C(NC(N(C)C)=O)N=CC2)C=CC=C1)C3=CC=4C(C=C3)=CN(C)N4
Molecular Formula
C24H25N7O2
Molecular Weight
443.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-[[2-(dimethylcarbamoylamino)pyridin-4-yl]methylamino]-N-(2-methylindazol-6-yl)benzamide
CAS Number886563-25-3
PubChem CID11554051
IUPAC Name2-[[2-(dimethylcarbamoylamino)-4-pyridinyl]methylamino]-N-(2-methylindazol-6-yl)benzamide
Molecular FormulaC24H25N7O2
Molecular Weight443.5
XLogP2.9
Topological Polar Surface Area104
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity675
SMILES
CN1C=C2C=CC(=CC2=N1)NC(=O)C3=CC=CC=C3NCC4=CC(=NC=C4)NC(=O)N(C)C
InChI
InChI=1S/C24H25N7O2/c1-30(2)24(33)28-22-12-16(10-11-25-22)14-26-20-7-5-4-6-19(20)23(32)27-18-9-8-17-15-31(3)29-21(17)13-18/h4-13,15,26H,14H2,1-3H3,(H,27,32)(H,25,28,33)
InChIKey
KYNHWVSHYKPILI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[[2-(dimethylcarbamoylamino)pyridin-4-yl]methylamino]-N-(2-methylindazol-6-yl)benzamide
CAS: 886563-25-3
CID: 11554051
Formula: C24H25N7O2
MW: 443.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight443.5
XLogP32.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass443.20697307
Monoisotopic Mass443.20697307
Topological Polar Surface Area104 Ų
Heavy Atom Count33
Formal Charge0
Complexity675
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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