Products for Research Use Only
RegisterLogin

ACBI3

CAT: 0804-HY-157228-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-157228-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ACBI3 (compound 7), a chemical probe, is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 (red part), E3 ligase ligand E3 ligase Ligand 43 (HY-401613) (blue part) and PROTAC Linker 1-Bromo-4- (ethynyloxy) butane (HY-169992) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 (HY-169995). ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models[1][2][3].
CAS Number
2938169-76-5
UNSPSC
12352005
Target
PROTACs; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/acbi3.html
Purity
99.47
Solubility
DMSO : 140 mg/mL (ultrasonic)
Smiles
NC(SC1=C2[C@](C3=NC(C4=NC(N5CCCN(CCCCOC(N=N6)=CN6[C@@H](C(C)C)C(N7[C@H](C(N[C@@H](CO)C8=CC=C(C=C8)C9=C(N=CS9)C)=O)C[C@@H](O)C7)=O)C[C@@H]5C)=NC=C4)=NO3)(C)CCC1)=C2C#N
Molecular Formula
C50H62N14O6S2
Molecular Weight
1019.25
References & Citations
[1]Popow J, et al. Targeting cancer with small molecule pan-KRAS degraders[J]. bioRxiv, 2023: 2023.10. 24.563163.|[2]Hamilton G, et al. Development of PROTACS degrading KRAS and SOS1. Oncol Res. 2024 Jul 17;32 (8) :1257-1264.|[3]Cox AD, et al. KRAS takes the road to destruction. Science. 2024 Sep 20;385 (6715) :1274-1275.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-151623-01ACBI2
HY-128359-01ACBI1
HY-176792-01ACBI-4
HY-176792A(R) -ACBI-4
HY-P87480ACBD3 Antibody (YA7167, Rabbit)
HY-RS00142ACBD3 Human Pre-designed siRNA Set A

Alternative Products

CatalogName
GTR19243477-01ACBI3

Popular Products