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11beta-Hydroxyprogesterone

CAT: 0804-HY-N2337-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N2337-01Size:5 mg
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Description
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
CAS Number
[600-57-7]
Product Name Alternative
11β-Hydroxyprogesterone
UNSPSC
12352211
Target
11β-HSD
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/11beta-Hydroxyprogesterone.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@@](C)([C@@H](C(C)=O)CC4)C[C@@H]3O
Molecular Formula
C21H30O3
Molecular Weight
330.47
References & Citations
[1]Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62 (6) :1306-13.|[2]Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27 (3 Pt 1) :421-5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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