NB-360

• Target :

  Beta-Secretase|||BACE

• Related Pathways :

  Neuroscience

• Purity :

  0.9972

• Bioactivity :

  NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.

• Smiles :

  Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N

• Molecular Formula :

  C21H19F4N5O2

• Molecular Weight :

  449.4

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1262857-73-7