NB-360

• Target:

  Beta-Secretase|||BACE

• Related Pathways:

  Neuroscience

• Purity:

  0.9972

• Bioactivity:

  NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.

• Smiles:

  Cc1cc (cnc1C (=O) Nc1ccc (F) c (c1) [C@]1 (C) CO[C@] (C) (C (N) =N1) C (F) (F) F) C#N

• Molecular Formula:

  C21H19F4N5O2

• Molecular Weight:

  449.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1262857-73-7