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NB-360

CAT: 0931-T12188-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T12188-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1262857-73-7
Target
Beta-Secretase, BACE
Related Pathways
Neuroscience
Purity
0.9972
Bioactivity
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.
Smiles
Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N
Molecular Formula
C21H19F4N5O2
Molecular Weight
449.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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