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M8891

CAT: 0931-T11930-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T11930-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1464842-09-8
Target
Others, Aminopeptidase
Related Pathways
Metabolism, Others
Bioactivity
M8891 is an orally active, reversible, and brain-penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor (IC50: 54 nM; Ki: 4.33 nM) . It inhibits the growth of primary endothelial cells and tumor cells, demonstrating both antiangiogenic and antitumoral activity.
Smiles
O[C@@]1(CCN(C1=O)c1ccc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(F)c1
Molecular Formula
C20H17F2N3O3
Molecular Weight
385.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

(3S)-N-[(3,5-difluorophenyl)methyl]-3-hydroxy-1-(1H-indol-5-yl)-2-oxopyrrolidine-3-carboxamide
CAS Number1464842-09-8
PubChem CID89855776
IUPAC Name(3S)-N-[(3,5-difluorophenyl)methyl]-3-hydroxy-1-(1H-indol-5-yl)-2-oxopyrrolidine-3-carboxamide
Molecular FormulaC20H17F2N3O3
Molecular Weight385.4
XLogP2.5
Topological Polar Surface Area85.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity612
SMILES
C1CN(C(=O)[C@]1(C(=O)NCC2=CC(=CC(=C2)F)F)O)C3=CC4=C(C=C3)NC=C4
InChI
InChI=1S/C20H17F2N3O3/c21-14-7-12(8-15(22)10-14)11-24-18(26)20(28)4-6-25(19(20)27)16-1-2-17-13(9-16)3-5-23-17/h1-3,5,7-10,23,28H,4,6,11H2,(H,24,26)/t20-/m0/s1
InChIKey
WVGGJQVCOTYFPV-FQEVSTJZSA-N
Chemical Structure
2D Structure
2D structure of (3S)-N-[(3,5-difluorophenyl)methyl]-3-hydroxy-1-(1H-indol-5-yl)-2-oxopyrrolidine-3-carboxamide
CAS: 1464842-09-8
CID: 89855776
Formula: C20H17F2N3O3
MW: 385.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight385.4
XLogP32.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass385.12379774
Monoisotopic Mass385.12379774
Topological Polar Surface Area85.4 Ų
Heavy Atom Count28
Formal Charge0
Complexity612
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA7971-1M8891
HY-133016A-01(R) -M8891

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