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Eltanexor

CAT: 0931-T11766L-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T11766L-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1642300-52-4
Target
CRM1, Others
Related Pathways
Others, Membrane transporter/Ion channel
Purity
0.9986
Bioactivity
Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines.
Smiles
NC(=O)C(=C\n1cnc(n1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)\c1cncnc1
Molecular Formula
C17H10F6N6O
Molecular Weight
428.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C