Products for Research Use Only
RegisterLogin

Eltanexor

CAT: 0804-HY-100423-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-100423-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines[1].
CAS Number
1642300-52-4
Product Name Alternative
KPT-8602
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CRM1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KPT-8602.html
Purity
99.84
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC(F)(F)C1=CC(C(F)(F)F)=CC(C2=NN(/C=C(C3=CN=CN=C3)/C(N)=O)C=N2)=C1
Molecular Formula
C17H10F6N6O
Molecular Weight
428.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Vercruysse T et al. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia. Clin Cancer Res. 2016 Oct 25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
MBS3602492-01Eltanexor
A17207-25Eltanexor 25mg
A17207-50Eltanexor 50mg
A17207-500Eltanexor 500mg
A17207-100Eltanexor 100mg
A17207-5Eltanexor 5mg
A17207-1Eltanexor 1mg
A17207-10Eltanexor 10mg
A17207-2Eltanexor 2mg
C13392-1gEltanexor (KPT-8602)

Popular Products