JTE-952

CAT: 0931-T11729-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T11729-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1255303-54-8
Target
C-Fms|||Histamine Receptor
Related Pathways
Neuroscience|||GPCR/G Protein|||Tyrosine Kinase/Adaptors|||Immunology/Inflammation
Bioactivity
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.
Smiles
C(=O)(N1CC(C1)C2=CC(OC)=C(OCC3=CC=C(C=C3)C4CC4)C=C2)C5=CC(COC[C@H](CO)O)=CC=N5
Molecular Formula
C30H34N2O6
Molecular Weight
518.6
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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