JTE-952

• Target:

  C-Fms|||Histamine Receptor

• Related Pathways:

  Neuroscience|||GPCR/G Protein|||Tyrosine Kinase/Adaptors|||Immunology/Inflammation

• Bioactivity:

  JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.

• Smiles:

  C(=O)(N1CC(C1)C2=CC(OC)=C(OCC3=CC=C(C=C3)C4CC4)C=C2)C5=CC(COC[C@H](CO)O)=CC=N5

• Molecular Formula:

  C30H34N2O6

• Molecular Weight:

  518.6

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1255303-54-8