J-113863

• Target:

  CCR

• Related Pathways:

  Microbiology/Virology|||GPCR/G Protein|||Immunology/Inflammation

• Purity:

  0.9511

• Bioactivity:

  J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM), but a weak antagonist of the mouse CCR3 (IC50 of 460 nM) . J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-? receptors. Anti-inflammatory effect. J-113863 is a potent and selective CCR1 (CD18) antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively.

• Smiles:

  [I-].CC[N+]1(C\C2=C\CCCCCC2)CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc12

• Molecular Formula:

  C30H37Cl2IN2O2

• Molecular Weight:

  655.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  353791-85-2